Rapid tissue engineering of biomimetic human corneal limbal crypts with 3D niche architecture
نویسندگان
چکیده
منابع مشابه
Limbal epithelial crypts: a novel anatomical structure and a putative limbal stem cell niche.
BACKGROUND/AIMS There is substantial evidence that mammalian epithelial stem cells are located within well defined niches. Although the corneoscleral limbus is acknowledged as the site of corneal epithelial stem cells no anatomical niche for such cells has yet been described. The authors undertook to re-evaluate the microanatomy of the limbus in order to identify possible sites that may represe...
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متن کاملStromal niche controls the plasticity of limbal and corneal epithelial differentiation in a rabbit model of recombined tissue.
PURPOSE The adult rabbit limbal basal epithelium contains corneal epithelial stem cells, which have been characterized by a negative expression of keratin-3 (K3) and a lower expression of connexin 43 (Cx43). This study was conducted to determine whether the limbal stroma dictates the plasticity of limbal and corneal epithelial differentiation. METHODS Viable epithelial sheets of the central c...
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ژورنال
عنوان ژورنال: Biomaterials
سال: 2013
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2013.08.002